Basic amino acid transport

Across TCGA patient cohorts, RNA activity of the Basic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASL12, MAMDC2, and HLF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basic amino acid transport activity versus RASL12 in LUAD (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RASL12 →	-0.461	-0.367	.004	.004	3	5
LUAD	MAMDC2 →	-1.008	-0.420	<.001	.001	3	5
LUAD	HLF →	-1.198	-0.410	.001	.001	3	4
BRCA	PLSCR4 →	-0.890	-0.683	<.001	<.001	3	4
CCRCC	THSD7B →	-0.819	-0.608	<.001	.001	3	4
BRCA	FRZB →	-0.974	-0.736	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015802 vs RASL12 — LUAD

Explore this scatter interactively →