Basic amino acid transport

Across TCGA cell cohorts, RNA activity of the Basic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFRL1, CHAF1B, and ANKRD18A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OGFRL1 grouped by Basic amino acid transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OGFRL1 →	-2.930	-1.503	<.001	.001	3	5
LARGE_INTESTINE	CHAF1B →	+0.629	+0.769	.003	.006	3	4
LARGE_INTESTINE	ANKRD18A →	+1.566	+1.168	.005	<.001	3	4
BONE	RIOK1 →	+1.156	+1.550	.003	.001	3	4
CNS	COA7 →	+0.680	+0.873	<.001	.007	3	4
BONE	EDEM1 →	-1.662	-1.867	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OGFRL1 by Basic amino acid transport activity — BONE

Explore this box plot interactively →