Basic amino acid transport

Across TCGA cell cohorts, RNA activity of the Basic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, SLC3A2, and UBE2B, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basic amino acid transport activity versus SLC7A5 in PANCREAS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC7A5 →	+2.590	+0.555	<.001	<.001	3	11
OVARY	SLC3A2 →	+1.317	+0.306	<.001	<.001	2	10
LIVER	UBE2B →	+0.759	+0.490	.002	<.001	3	5
SKIN	ADAM22 →	-0.970	-0.343	.003	<.001	3	5
LARGE_INTESTINE	C5orf15 →	+0.669	+0.272	.001	.001	3	5
LARGE_INTESTINE	CAPN5 →	-2.826	-0.443	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015802 vs SLC7A5 — PANCREAS

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