Aromatic amino acid transport

Across TCGA patient cohorts, RNA activity of the Aromatic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFRA1, PLSCR4, and AOX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid transport activity versus GFRA1 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GFRA1 →	-0.878	-0.207	<.001	.004	3	4
LUAD	PLSCR4 →	-0.648	-0.446	<.001	<.001	3	3
OV	AOX1 →	-1.085	-0.179	.004	.001	2	4
LUAD	MS4A2 →	-0.865	-0.336	.001	.002	3	3
LUAD	GCSAML →	-0.356	-0.365	<.001	.002	3	3
LUAD	HMGB3 →	+0.780	+0.243	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015801 vs GFRA1 — LUAD

Explore this scatter interactively →