Aromatic amino acid transport

Across TCGA cell cohorts, RNA activity of the Aromatic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST13, VWA8, and VBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST13 grouped by Aromatic amino acid transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ST13 →	-0.715	-1.110	<.001	.001	3	3
LIVER	VWA8 →	-0.953	-1.299	<.001	<.001	3	3
LIVER	VBP1 →	+0.860	+1.149	.007	.003	3	3
LIVER	TMEM126A →	+1.228	+1.253	.006	.002	3	3
LIVER	ABAT →	-2.373	-0.988	.001	.002	3	3
LIVER	PICALM →	+1.189	+1.342	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST13 by Aromatic amino acid transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →