Aromatic amino acid transport

Across TCGA cell cohorts, RNA activity of the Aromatic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, SLC3A2, and DGAT2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid transport activity versus SLC7A5 in LUNG_NSCLC_LUAD (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC7A5 →	+2.280	+0.352	<.001	<.001	3	13
OESOPHAGUS	SLC3A2 →	+1.761	+0.290	.001	<.001	3	11
URINARY_TRACT	DGAT2 →	-1.800	-0.339	.002	.003	3	5
BLOOD_Lymphoma	APOL1 →	+2.977	+0.228	<.001	.001	3	5
BLOOD_Lymphoma	SRXN1 →	+1.248	+0.232	.006	.002	3	5
SOFT_TISSUE	POLR2E →	-0.524	-0.248	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015801 vs SLC7A5 — LUNG_NSCLC_LUAD

Explore this scatter interactively →