Aromatic amino acid transport

Across TCGA cell cohorts, RNA activity of the Aromatic amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC7A5, SLC3A2, and PDE3A, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid transport activity versus SLC7A5 in LIVER (Pearson r = 0.90).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC7A5 →	+2.937	+0.489	<.001	.002	3	19
URINARY_TRACT	SLC3A2 →	+2.169	+0.457	.001	.001	3	19
OESOPHAGUS	PDE3A →	+1.513	+0.202	<.001	<.001	3	11
LUNG_NSCLC_LUAD	CLIC1 →	-1.843	-0.255	<.001	<.001	3	8
URINARY_TRACT	PAFAH1B3 →	-2.868	-0.476	<.001	<.001	3	8
URINARY_TRACT	TPI1 →	-2.617	-0.344	.003	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015801 vs SLC7A5 — LIVER

Explore this scatter interactively →