Acidic amino acid transport

Across TCGA patient cohorts, RNA activity of the Acidic amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL34_S12, OSBPL7_S272, and NRCAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acidic amino acid transport activity versus RPL34_S12 in PDAC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPL34_S12 →	+0.470	+0.024	<.001	.006	3	4
COAD	OSBPL7_S272 →	-0.381	-0.026	.002	<.001	3	4
GBM	NRCAM →	+0.579	+0.062	<.001	<.001	3	4
GBM	ASF1A_S166 →	-0.378	-0.040	<.001	<.001	3	4
GBM	SRRM2_S1424 →	-0.492	-0.050	.001	<.001	3	4
GBM	TCF12 →	-0.274	-0.052	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015800 vs RPL34_S12 — PDAC

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