Acidic amino acid transport

Across TCGA cell cohorts, RNA activity of the Acidic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0E1, PEX16, and ABHD10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V0E1 grouped by Acidic amino acid transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ATP6V0E1 →	-0.527	-0.996	.004	.002	3	5
LUNG_SCLC	PEX16 →	-0.652	-0.930	<.001	.003	3	5
LUNG_NSCLC_LUAD	ABHD10 →	+0.590	+1.030	.001	.001	3	4
BLOOD_Lymphoma	RPS6KA6 →	+2.623	+1.920	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SNAP29 →	-0.998	-1.389	<.001	.004	2	5
BLOOD_Myeloma	SHROOM1 →	-1.448	-1.507	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V0E1 by Acidic amino acid transport activity — STOMACH

Explore this box plot interactively →