Acidic amino acid transport

Across TCGA cell cohorts, RNA activity of the Acidic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2H, HDGFL3, and IQCB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acidic amino acid transport activity versus UBE2H in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBE2H →	+0.941	+0.240	.005	.005	3	5
SKIN	HDGFL3 →	-0.923	-0.221	.006	.001	3	4
PANCREAS	IQCB1 →	-0.537	-0.264	.006	.002	3	4
PANCREAS	RHBDD2 →	+0.890	+0.289	.008	.002	3	4
STOMACH	CENPV →	-1.511	-0.272	.007	.006	2	5
LUNG_SCLC	TIA1 →	-0.876	-0.553	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015800 vs UBE2H — LARGE_INTESTINE

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