Glycerol transmembrane transport

Across TCGA patient cohorts, RNA activity of the Glycerol transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTI1, NXT2, and MAGT1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerol transmembrane transport activity versus TTI1 in CCRCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TTI1 →	-0.346	-0.137	.001	.006	3	1
CCRCC	NXT2 →	-0.290	-0.107	.001	.007	3	1
CCRCC	MAGT1 →	-0.333	-0.151	.003	.004	3	1
CCRCC	NOMO3 →	-0.762	-0.161	<.001	<.001	3	1
CCRCC	KAZALD1 →	+0.380	+0.152	.001	.005	3	1
CCRCC	PITRM1 →	-0.372	-0.159	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015793 vs TTI1 — CCRCC

Explore this scatter interactively →