Glycerol transmembrane transport

Across TCGA cell cohorts, RNA activity of the Glycerol transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF837, RAB40A, and SPATA46, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF837 grouped by Glycerol transmembrane transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF837 →	+0.506	+0.736	.002	.001	3	5
LUNG_NSCLC_LUSC	RAB40A →	+0.731	+1.269	.003	.009	3	4
KIDNEY	SPATA46 →	+0.125	+0.976	.001	.002	3	4
BREAST	C1orf226 →	+1.272	+0.872	.001	<.001	3	4
BREAST	CAMK2B →	+1.495	+1.074	.009	<.001	3	4
CNS	CHCHD10 →	-1.592	-0.849	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF837 by Glycerol transmembrane transport activity — BREAST

Explore this box plot interactively →