Glycerol transmembrane transport

Across TCGA cell cohorts, RNA activity of the Glycerol transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLA2, CLTC, and NXF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLA2 grouped by Glycerol transmembrane transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	POLA2 →	+0.312	+1.552	<.001	<.001	3	5
LARGE_INTESTINE	CLTC →	+0.380	+1.119	.001	.002	3	5
BREAST	NXF1 →	+0.494	+1.346	.008	<.001	3	5
STOMACH	PRIM2 →	+0.382	+1.613	<.001	<.001	3	4
URINARY_TRACT	GRK3 →	-0.385	-2.168	<.001	<.001	3	4
URINARY_TRACT	HTR4 →	-0.333	-1.891	.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLA2 by Glycerol transmembrane transport activity — STOMACH

Explore this box plot interactively →