Polyol transmembrane transport

Across TCGA patient cohorts, RNA activity of the Polyol transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC26A6, MAMDC2-AS1, and RNU2-5P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol transmembrane transport activity versus SLC26A6 in PDAC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC26A6 →	+0.351	+0.247	.007	<.001	3	5
LUAD	MAMDC2-AS1 →	-0.379	-0.588	.003	<.001	3	4
LUAD	RNU2-5P →	-0.616	-0.629	<.001	.003	2	5
LUAD	LINC00683 →	-0.196	-0.726	<.001	<.001	3	4
LSCC	MAMDC2 →	-0.971	-0.869	<.001	<.001	3	4
GBM	EGR1 →	-0.784	-0.789	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015791 vs SLC26A6 — PDAC

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