Nucleotide-sugar transmembrane transport

Across TCGA patient cohorts, RNA activity of the Nucleotide-sugar transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYH9_S1943, PLEKHA7_S903, and ABHD14B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar transmembrane transport activity versus MYH9_S1943 in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYH9_S1943 →	-0.453	-0.042	<.001	.008	3	5
LSCC	PLEKHA7_S903 →	+0.728	+0.048	<.001	<.001	3	5
PDAC	ABHD14B →	+0.345	+0.060	.001	<.001	3	5
PDAC	MAP4_S696 →	-0.609	-0.055	<.001	<.001	3	5
HNSC	FOSL2_S230 →	-0.433	-0.067	<.001	<.001	3	5
BRCA	SNX4 →	+0.204	+0.029	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015780 vs MYH9_S1943 — LSCC

Explore this scatter interactively →