Nucleotide-sugar transmembrane transport

Across TCGA patient cohorts, RNA activity of the Nucleotide-sugar transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOK6, LINC00862, and CSTF2T, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar transmembrane transport activity versus DOK6 in LSCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOK6 →	-0.514	-0.336	.005	.002	3	3
LUAD	LINC00862 →	+0.650	+0.408	.001	.003	3	3
CCRCC	CSTF2T →	-0.160	-0.323	.004	.005	3	3
HNSC	TREML4 →	+0.370	+0.620	.009	<.001	3	2
HNSC	PLIN5 →	+0.333	+0.376	.007	.002	3	2
HNSC	MTCYBP10 →	+0.221	+0.598	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015780 vs DOK6 — LSCC

Explore this scatter interactively →