Nucleotide-sugar transmembrane transport

Across TCGA cell cohorts, RNA activity of the Nucleotide-sugar transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN2, TRAP1, and HNRNPU, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN2 grouped by Nucleotide-sugar transmembrane transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZSCAN2 →	-0.829	-0.944	.002	.008	3	5
UPPER_AERODIGESTIVE_TRACT	TRAP1 →	+1.211	+1.303	<.001	<.001	3	4
LUNG_SCLC	HNRNPU →	-0.721	-0.463	<.001	.006	3	4
BLOOD_Leukemia	RITA1 →	+0.792	+0.774	.001	<.001	3	4
OESOPHAGUS	DUSP4 →	+2.748	+1.496	.003	.003	3	4
OESOPHAGUS	C6orf89 →	+0.579	+1.606	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN2 by Nucleotide-sugar transmembrane transport activity — OVARY

Explore this box plot interactively →