Nucleotide-sugar transmembrane transport

Across TCGA cell cohorts, RNA activity of the Nucleotide-sugar transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCOR2, NUFIP2, and CPSF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCOR2 grouped by Nucleotide-sugar transmembrane transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RCOR2 →	-0.134	-0.070	.001	.003	3	5
LUNG_SCLC	NUFIP2 →	-0.170	-0.082	.003	.008	3	4
OVARY	CPSF3 →	-0.230	-0.096	.003	<.001	3	4
CNS	CYP2W1 →	-0.276	-0.095	<.001	.001	3	4
STOMACH	HECTD3 →	-0.194	-0.089	<.001	.002	3	4
CNS	UBAC1 →	-0.140	-0.093	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCOR2 by Nucleotide-sugar transmembrane transport activity — PANCREAS

Explore this box plot interactively →