Galactose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Galactose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A3, SLC2A10, and FAM114A1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose transmembrane transport activity versus SLC2A3 in UVM (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SLC2A3 →	+1.748	+0.110	<.001	<.001	3	30
CHOL	SLC2A10 →	+1.984	+0.128	.004	<.001	2	29
THYM	FAM114A1 →	+0.818	+0.063	<.001	<.001	3	24
SARC	KDELR3 →	+1.158	+0.065	<.001	<.001	3	23
UVM	SEC24D →	+0.910	+0.090	<.001	<.001	3	23
UVM	BTBD19 →	+1.175	+0.088	.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015757 vs SLC2A3 — UVM

Explore this scatter interactively →