Galactose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Galactose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A3, ABCA6, and AQP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose transmembrane transport activity versus SLC2A3 in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC2A3 →	+1.346	+1.047	<.001	<.001	3	4
CCRCC	ABCA6 →	-0.788	-0.283	<.001	.003	3	3
LUAD	AQP9 →	+1.081	+0.605	<.001	.001	3	3
LSCC	PLAUR →	+0.589	+0.689	<.001	<.001	3	3
LSCC	IL1A →	+1.358	+0.567	<.001	.007	3	3
LUAD	SNAI1 →	+0.758	+0.507	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015757 vs SLC2A3 — LSCC

Explore this scatter interactively →