Fructose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Fructose transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC2A5, CD14, and IL4I1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose transmembrane transport activity versus SLC2A5 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC2A5 →	+0.781	+0.082	<.001	<.001	3	8
GBM	CD14 →	+0.626	+0.068	<.001	<.001	3	7
COAD	IL4I1 →	+0.687	+0.045	<.001	.002	3	7
GBM	PARVG →	+0.482	+0.074	<.001	<.001	3	7
GBM	NCF2 →	+0.504	+0.048	<.001	<.001	3	7
GBM	COPZ2 →	+0.414	+0.044	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015755 vs SLC2A5 — GBM

Explore this scatter interactively →