Fructose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Fructose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, AQP9, and CNTRL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose transmembrane transport activity versus BCL2A1 in PDAC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BCL2A1 →	+0.985	+0.177	<.001	.006	3	5
PDAC	AQP9 →	+1.113	+0.251	.001	<.001	2	5
PDAC	CNTRL →	-0.307	-0.200	.003	.007	3	4
BRCA	S100A8 →	+4.240	+0.199	<.001	<.001	3	4
PDAC	PLOD2 →	+0.533	+0.174	.009	.003	3	4
PDAC	TNNI1 →	-0.406	-0.187	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015755 vs BCL2A1 — PDAC

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