Fructose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Fructose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC6, CSF2RA, and PRKCH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXOSC6 grouped by Fructose transmembrane transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EXOSC6 →	+0.691	+1.550	.002	<.001	3	3
LARGE_INTESTINE	CSF2RA →	+2.375	+1.327	<.001	<.001	3	3
LARGE_INTESTINE	PRKCH →	+1.954	+1.145	<.001	.004	3	3
LUNG_NSCLC_LUAD	MTPAP →	-0.524	-0.859	.001	.007	3	3
OESOPHAGUS	ABHD11 →	-1.145	-1.203	.005	.007	3	3
CNS	CASK →	+0.894	+1.564	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXOSC6 by Fructose transmembrane transport activity — KIDNEY

Explore this box plot interactively →