Organophosphate ester transport

Across TCGA patient cohorts, RNA activity of the Organophosphate ester transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, RPL7L1, and SEPTIN1_S206, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organophosphate ester transport activity versus SAMHD1 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMHD1 →	+0.358	+0.029	<.001	<.001	3	7
PDAC	RPL7L1 →	-0.361	-0.025	<.001	.002	3	6
BRCA	SEPTIN1_S206 →	+0.831	+0.017	.001	.001	3	6
UCEC	TFEB →	+0.401	+0.031	<.001	.004	3	6
GBM	BIN1 →	+0.578	+0.031	<.001	<.001	3	6
LSCC	EVL_S246 →	+0.547	+0.024	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015748 vs SAMHD1 — LSCC

Explore this scatter interactively →