Organophosphate ester transport

Across TCGA patient cohorts, RNA activity of the Organophosphate ester transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMSAP2, RAB3GAP2, and NUCKS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organophosphate ester transport activity versus CAMSAP2 in UCEC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CAMSAP2 →	-0.389	-0.225	.003	.007	3	4
UCEC	RAB3GAP2 →	-0.537	-0.317	.001	.001	3	4
UCEC	NUCKS1 →	-0.497	-0.250	<.001	<.001	3	4
UCEC	POLA1 →	-0.329	-0.202	.001	.002	3	4
UCEC	CASP8AP2 →	-0.316	-0.240	.004	.004	3	4
UCEC	PHF3 →	-0.347	-0.341	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015748 vs CAMSAP2 — UCEC

Explore this scatter interactively →