Organophosphate ester transport

Across TCGA cell cohorts, RNA activity of the Organophosphate ester transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JOSD2, CHPF2, and NKX6-1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JOSD2 grouped by Organophosphate ester transport-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	JOSD2 →	-2.481	-1.446	.002	<.001	3	6
BLOOD_Myeloma	CHPF2 →	-0.929	-1.271	<.001	<.001	3	5
LUNG_SCLC	NKX6-1 →	+1.076	+1.218	.005	<.001	3	4
LUNG_NSCLC_LUAD	SLC3A2 →	+1.143	+1.082	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TUBA8 →	+0.471	+0.714	<.001	<.001	3	4
LUNG_NSCLC_LUAD	KLHDC8B →	-0.755	-0.641	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JOSD2 by Organophosphate ester transport activity — LIVER

Explore this box plot interactively →