Organophosphate ester transport

Across TCGA cell cohorts, RNA activity of the Organophosphate ester transport pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BABAM2, SLC2A12, and SLC45A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BABAM2 grouped by Organophosphate ester transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BABAM2 →	-0.195	-0.036	<.001	<.001	3	4
SKIN	SLC2A12 →	-0.252	-0.042	.001	<.001	3	4
LUNG_NSCLC_LUAD	SLC45A3 →	-0.119	-0.032	<.001	<.001	3	4
BLOOD_Leukemia	AMD1 →	+0.224	+0.031	.005	.007	3	4
UPPER_AERODIGESTIVE_TRACT	PPP3CC →	+0.174	+0.047	.007	.004	3	4
UPPER_AERODIGESTIVE_TRACT	IL10 →	-0.108	-0.038	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BABAM2 by Organophosphate ester transport activity — CNS

Explore this box plot interactively →