Organophosphate ester transport

Across TCGA cell cohorts, RNA activity of the Organophosphate ester transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGK, RPL10A, and RPS13, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organophosphate ester transport activity versus NAGK in BONE (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NAGK →	+1.405	+0.400	<.001	<.001	3	9
OVARY	RPL10A →	-0.646	-0.178	<.001	<.001	3	8
OVARY	RPS13 →	-0.895	-0.171	.005	.002	3	7
LUNG_SCLC	RPL4 →	-0.960	-0.218	<.001	.001	3	7
STOMACH	SMPD1 →	+1.708	+0.257	.005	.005	3	7
BONE	THBS1 →	+4.861	+0.371	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015748 vs NAGK — BONE

Explore this scatter interactively →