Urate transport

Across TCGA patient cohorts, RNA activity of the Urate transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC4, KCND2, and THNSL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urate transport activity versus ABCC4 in OV (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ABCC4 →	+1.103	+0.650	.001	.005	3	5
PDAC	KCND2 →	+0.467	+0.433	.006	.004	3	4
BRCA	THNSL1 →	-0.598	-0.794	.004	.002	3	3
BRCA	ADCY2 →	+0.904	+1.032	<.001	<.001	3	3
COAD	ADRA2C →	+0.855	+0.512	.001	.008	2	4
GBM	CKS1B →	-0.308	-0.185	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015747 vs ABCC4 — OV

Explore this scatter interactively →