Urate transport

Across TCGA cell cohorts, RNA activity of the Urate transport pathway is significantly associated with the drug response of multiple features, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AZD1480, PARP_9482, and Sabutoclax, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AZD1480 grouped by Urate transport-low versus -high activity in OESOPHAGUS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AZD1480 →	-0.882	-0.386	.002	.047	3	3
OESOPHAGUS	PARP_9482 →	-1.470	-0.635	.025	.017	3	3
OESOPHAGUS	Sabutoclax →	-0.630	-0.445	.023	.039	3	3
OESOPHAGUS	AKT inhibitor VIII →	+1.714	+0.393	.021	.017	3	3
OESOPHAGUS	PI-103 →	+2.087	+0.445	.009	.009	3	3
LUNG_NSCLC_LUAD	VTP-A →	+0.346	+0.538	.005	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD1480 by Urate transport activity — OESOPHAGUS

Explore this box plot interactively →