Citrate transport

Across TCGA patient cohorts, RNA activity of the Citrate transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HK2, ENG, and HSPA14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrate transport activity versus HK2 in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HK2 →	+0.366	+0.043	<.001	.002	3	5
UCEC	ENG →	-0.402	-0.089	<.001	<.001	3	5
LSCC	HSPA14 →	+0.342	+0.068	<.001	<.001	3	5
LSCC	DARS1 →	+0.166	+0.055	<.001	.002	3	5
LSCC	DNAJC2 →	+0.419	+0.084	<.001	<.001	3	4
LUAD	EPN1 →	-0.187	-0.058	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015746 vs HK2 — LSCC

Explore this scatter interactively →