Citrate transport

Across TCGA patient cohorts, RNA activity of the Citrate transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GNT4, C4BPAP2, and STON1-GTF2A1L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrate transport activity versus B3GNT4 in UCEC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	B3GNT4 →	-0.394	-0.885	.009	.004	3	2
UCEC	C4BPAP2 →	+0.763	+0.809	.005	.004	3	2
UCEC	STON1-GTF2A1L →	+0.139	+0.807	.005	<.001	3	2
LSCC	SLFN13 →	-1.486	-1.370	.002	.003	3	2
LSCC	RPL7P22 →	-0.231	-1.024	.003	.005	3	2
LSCC	SNRPFP2 →	-0.784	-1.402	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015746 vs B3GNT4 — UCEC

Explore this scatter interactively →