Alpha-ketoglutarate transport

Across TCGA patient cohorts, RNA activity of the Alpha-ketoglutarate transport pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A21, DYNC2H1, and TTC28, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-ketoglutarate transport activity versus SLC25A21 in CHOL (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	SLC25A21 →	-0.764	-0.237	<.001	<.001	3	31
CHOL	DYNC2H1 →	-1.248	-0.267	<.001	<.001	3	24
CHOL	TTC28 →	-1.052	-0.176	.001	.002	2	24
THYM	BMPR2 →	-1.249	-0.093	<.001	<.001	3	23
SARC	MIPOL1 →	-0.437	-0.093	<.001	<.001	3	23
THYM	KIDINS220 →	-1.096	-0.058	<.001	<.001	2	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015742 vs SLC25A21 — CHOL

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