Taurine transmembrane transport

Across TCGA patient cohorts, RNA activity of the Taurine transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, RIN3, and WAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Taurine transmembrane transport activity versus WIPF1 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WIPF1 →	+0.355	+0.092	<.001	<.001	3	7
GBM	RIN3 →	+0.385	+0.062	<.001	.001	3	6
GBM	WAS →	+0.433	+0.070	<.001	<.001	3	6
GBM	BIN2 →	+0.510	+0.064	<.001	<.001	3	6
GBM	ADAP2 →	+0.458	+0.073	.001	<.001	3	6
GBM	HCLS1 →	+0.552	+0.069	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015734 vs WIPF1 — LSCC

Explore this scatter interactively →