Taurine transmembrane transport

Across TCGA patient cohorts, RNA activity of the Taurine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CISH, NPM1P49, and NCS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Taurine transmembrane transport activity versus CISH in CCRCC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CISH →	+0.716	+0.915	<.001	<.001	3	3
BRCA	NPM1P49 →	-0.119	-0.143	.008	.005	3	3
HNSC	NCS1 →	+0.861	+0.808	.002	.001	3	3
HNSC	LRRC8A →	+1.134	+0.684	<.001	.009	3	3
HNSC	PLCB2 →	-0.653	-0.749	.001	<.001	3	3
HNSC	ITPR1-DT →	-0.341	-0.671	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015734 vs CISH — CCRCC

Explore this scatter interactively →