Taurine transmembrane transport

Across TCGA patient cohorts, RNA activity of the Taurine transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRRC8A, LRRC8A_S217, and ITGB4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Taurine transmembrane transport activity versus LRRC8A in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LRRC8A →	+0.386	+0.569	<.001	.001	2	5
BRCA	LRRC8A_S217 →	+0.493	+0.133	.001	.009	2	5
HNSC	ITGB4 →	+0.670	+1.034	<.001	<.001	3	3
CCRCC	ARPC5 →	-0.257	-1.023	<.001	<.001	3	3
HNSC	LRRC8A_S193 →	+0.766	+0.919	<.001	<.001	3	3
CCRCC	MACF1_S4521 →	+0.557	+1.281	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015734 vs LRRC8A — UCEC

Explore this scatter interactively →