Taurine transmembrane transport

Across TCGA cell cohorts, RNA activity of the Taurine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5F1E, SYTL2, and ELF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5F1E grouped by Taurine transmembrane transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ATP5F1E →	-0.812	-1.025	<.001	.001	3	4
CNS	SYTL2 →	-2.467	-1.201	<.001	<.001	3	4
BONE	ELF2 →	+0.533	+1.519	.002	.006	3	4
BONE	STOX1 →	+1.111	+1.814	.003	<.001	3	4
CNS	PHLDA1 →	-1.924	-0.937	<.001	.003	3	4
CNS	RGL1 →	-1.251	-0.935	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5F1E by Taurine transmembrane transport activity — PANCREAS

Explore this box plot interactively →