Taurine transmembrane transport

Across TCGA cell cohorts, RNA activity of the Taurine transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP10, SFTPA2, and TBX21, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIP10 grouped by Taurine transmembrane transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIP10 →	-0.146	-0.357	.001	.003	3	2
CNS	SFTPA2 →	-0.339	-1.939	.007	<.001	3	2
CNS	TBX21 →	-0.530	-1.939	.005	<.001	3	2
LUNG_NSCLC_LUAD	OR1D2 →	+0.190	+0.322	.003	<.001	3	1
PANCREAS	TXNRD1 →	+0.285	+1.962	.005	.001	3	1
KIDNEY	TJP1 →	-0.270	-0.301	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIP10 by Taurine transmembrane transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →