Taurine transmembrane transport

Across TCGA cell cohorts, RNA activity of the Taurine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLRX5, RANBP17, and YBX3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Taurine transmembrane transport activity versus GLRX5 in PANCREAS (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GLRX5 →	-1.240	-2.050	.001	.002	3	3
PANCREAS	RANBP17 →	-2.270	-1.962	<.001	.001	3	3
KIDNEY	YBX3 →	-1.043	-0.345	.006	.009	3	2
LUNG_NSCLC_LUAD	CPLX4 →	-0.030	-0.315	.009	.002	3	2
LUNG_NSCLC_LUAD	ADAMTS20 →	-0.502	-0.292	.003	.001	3	2
LUNG_NSCLC_LUAD	PPARA →	-1.313	-0.383	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015734 vs GLRX5 — PANCREAS

Explore this scatter interactively →