Bile acid and bile salt transport

Across TCGA patient cohorts, RNA activity of the Bile acid and bile salt transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TALDO1, TKT, and TST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid and bile salt transport activity versus TALDO1 in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TALDO1 →	+0.458	+0.065	<.001	<.001	3	5
LSCC	TKT →	+0.289	+0.045	<.001	<.001	3	5
LSCC	TST →	+0.427	+0.064	<.001	.001	3	5
UCEC	CRAT →	+0.934	+0.072	<.001	.004	3	5
OV	GALK2 →	+0.719	+0.044	.004	.005	3	5
LSCC	SLC9A3R1 →	+0.601	+0.072	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015721 vs TALDO1 — LSCC

Explore this scatter interactively →