Bile acid and bile salt transport

Across TCGA cell cohorts, RNA activity of the Bile acid and bile salt transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM7, ACBD7, and GUCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM7 grouped by Bile acid and bile salt transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRIM7 →	-1.695	-0.371	.004	.006	2	5
BLOOD_Leukemia	ACBD7 →	+1.540	+0.760	.003	.007	3	4
LUNG_NSCLC_LUAD	GUCD1 →	-0.560	-0.633	.004	.007	3	4
BLOOD_Leukemia	UBAP2 →	+0.840	+0.720	.002	.007	3	4
LARGE_INTESTINE	LPXN →	-1.299	-0.689	<.001	<.001	3	3
LARGE_INTESTINE	CCDC121 →	+0.464	+0.624	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM7 by Bile acid and bile salt transport activity — SOFT_TISSUE

Explore this box plot interactively →