Bile acid and bile salt transport

Across TCGA cell cohorts, RNA activity of the Bile acid and bile salt transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MITD1, ATG10, and LATS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid and bile salt transport activity versus MITD1 in CNS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MITD1 →	+0.507	+0.969	.002	.001	3	4
SKIN	ATG10 →	+0.399	+1.102	<.001	<.001	3	4
LUNG_SCLC	LATS2 →	+1.718	+0.895	.007	.003	3	4
LIVER	MOSMO →	-0.580	-1.532	.006	<.001	3	4
BLOOD_Lymphoma	TM9SF2 →	+1.169	+0.238	.001	.009	3	4
BLOOD_Lymphoma	ACTN4 →	+0.996	+0.277	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015721 vs MITD1 — CNS

Explore this scatter interactively →