Hexose phosphate transport

Across TCGA patient cohorts, RNA activity of the Hexose phosphate transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PYCARD, GRAMD2B_S72, and DOCK10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hexose phosphate transport activity versus PYCARD in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PYCARD →	+0.445	+0.058	.001	.001	3	5
COAD	GRAMD2B_S72 →	+0.331	+0.064	<.001	<.001	3	5
GBM	DOCK10 →	+0.292	+0.058	.002	<.001	3	5
BRCA	LGALS9 →	+0.457	+0.059	<.001	<.001	3	5
GBM	MTA1 →	-0.337	-0.062	<.001	<.001	3	5
OV	APOBR →	+0.327	+0.052	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015712 vs PYCARD — GBM

Explore this scatter interactively →