Hexose phosphate transport

Across TCGA cell cohorts, RNA activity of the Hexose phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC37A1, RASSF8, and LLGL2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hexose phosphate transport activity versus SLC37A1 in LUNG_SCLC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC37A1 →	+2.071	+0.433	<.001	<.001	3	13
LARGE_INTESTINE	RASSF8 →	-1.750	-0.250	<.001	<.001	3	12
STOMACH	LLGL2 →	+2.354	+0.175	<.001	<.001	3	11
LARGE_INTESTINE	FRMD6 →	-1.977	-0.231	<.001	<.001	3	10
OVARY	ZEB1 →	-2.033	-0.506	<.001	.005	2	11
BREAST	DZIP1L →	-1.326	-0.279	.001	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015712 vs SLC37A1 — LUNG_SCLC

Explore this scatter interactively →