Iodide transport

Across TCGA patient cohorts, RNA activity of the Iodide transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANO1, ASAP2_S701, and EFNB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iodide transport activity versus ANO1 in HNSC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANO1 →	+1.443	+0.133	<.001	<.001	3	5
LUAD	ASAP2_S701 →	+0.545	+0.055	.003	.009	2	5
COAD	EFNB2 →	+0.502	+0.058	<.001	.002	3	4
GBM	ITPRID2 →	+0.261	+0.039	<.001	<.001	3	4
PDAC	SLK →	+0.154	+0.061	.001	<.001	3	4
OV	TCOF1_S156 →	-1.166	-0.083	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015705 vs ANO1 — HNSC

Explore this scatter interactively →