Iodide transport

Across TCGA patient cohorts, RNA activity of the Iodide transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FASN, HUS1, and NCAPH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iodide transport activity versus FASN in UCEC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	-0.824	-0.464	<.001	.007	3	4
GBM	HUS1 →	-0.266	-0.722	.006	<.001	3	4
UCEC	NCAPH →	-0.540	-0.466	.007	.008	3	3
UCEC	IQGAP3 →	-0.901	-0.508	<.001	.001	3	3
UCEC	CENPW →	-0.983	-0.501	.001	.005	3	3
LSCC	CC2D2A →	+0.357	+0.730	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015705 vs FASN — UCEC

Explore this scatter interactively →