Iodide transport

Across TCGA cell cohorts, RNA activity of the Iodide transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFNA1, B4GALT1, and ATP1B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EFNA1 grouped by Iodide transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EFNA1 →	-1.554	-0.714	.003	.008	3	4
LUNG_NSCLC_LUAD	B4GALT1 →	-0.947	-0.879	.007	.006	2	5
UPPER_AERODIGESTIVE_TRACT	ATP1B1 →	-1.560	-1.187	.008	.003	3	3
STOMACH	NIF3L1 →	+0.517	+1.082	.006	.002	3	3
STOMACH	H6PD →	-0.925	-1.182	.005	.001	2	4
PANCREAS	CWC27 →	+0.563	+1.606	.002	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EFNA1 by Iodide transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →