Iodide transport

Across TCGA cell cohorts, RNA activity of the Iodide transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHISA4, TLN1, and JAZF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iodide transport activity versus SHISA4 in BONE (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SHISA4 →	-1.811	-0.209	<.001	<.001	3	10
BONE	TLN1 →	-1.199	-0.238	<.001	<.001	3	8
BONE	JAZF1 →	-1.756	-0.224	.003	.002	3	8
BREAST	GLIPR2 →	-1.693	-0.178	.005	<.001	3	8
PANCREAS	STXBP1 →	-1.180	-0.158	<.001	.001	3	7
LARGE_INTESTINE	TPST1 →	-1.756	-0.174	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015705 vs SHISA4 — BONE

Explore this scatter interactively →