Bicarbonate transport

Across TCGA cell cohorts, RNA activity of the Bicarbonate transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCYOX1L, EZH1, and TMEM130, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCYOX1L grouped by Bicarbonate transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PCYOX1L →	+1.140	+1.111	.001	.001	3	5
STOMACH	EZH1 →	+0.574	+0.839	.007	.001	3	3
BREAST	TMEM130 →	+0.160	+0.751	.005	<.001	3	3
BREAST	TECPR1 →	+0.587	+0.670	.006	.007	2	4
BLOOD_Lymphoma	HMOX2 →	+0.830	+2.095	<.001	.006	3	3
PANCREAS	CCRL2 →	+1.410	+0.808	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCYOX1L by Bicarbonate transport activity — OVARY

Explore this box plot interactively →