Bicarbonate transport

Across TCGA cell cohorts, RNA activity of the Bicarbonate transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS9D1, ZER1, and ZNF362, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bicarbonate transport activity versus VPS9D1 in OESOPHAGUS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VPS9D1 →	-1.200	-0.111	<.001	.001	3	11
LUNG_SCLC	ZER1 →	-0.680	-0.073	.003	.002	3	10
KIDNEY	ZNF362 →	-1.072	-0.101	.005	<.001	3	9
OVARY	HECTD4 →	-0.658	-0.067	<.001	.003	3	9
LIVER	PLXNA3 →	-1.416	-0.065	.003	.005	2	9
BLOOD_Leukemia	TINF2 →	-0.625	-0.079	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015701 vs VPS9D1 — OESOPHAGUS

Explore this scatter interactively →